Treating Cancer as an Infectious Disease
Wang XG, Revskaya E, Bryan RA, et al. Treating cancer as an infectious disease–viral antigens as novel targets for treatment and potential prevention of tumors of viral etiology. PLoS ONE. 2007 Oct 31;2(10):e1114. PMID: 17971877
A fascinating paper by researchers at Albert Einstein College of Medicine in New York.
From the discussion:
"We performed in vitro and in vivo experiments to assess a novel strategy to treat virus associated tumors using radiolabeled mAbs targeted against viral proteins. This strategy is fundamentally different from prior uses of [radioimmunotherapy] in oncology that target tumor-associated human antigens thus resulting in significant uptake of radioactive antibody in normal tissues, leading to toxicity. The results of our study suggest that by targeting instead viral and not self-proteins it may be possible for radiolabeled mAbs to concentrate more specifically within tumor tissue, resulting in greater efficacy and less toxicity. This strategy also raises an exciting additional possibility to prevent virus-associated cancers in chronically infected patients by eliminating cells infected with oncogenic viruses before they transform into cancer."
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