Systems Biology and Cancer Stem Cells
Price ND, Foltz G, Madan A, et al. Systems biology and cancer stem cells. J Cell Mol Med. 2008 Jan-Feb;12(1):97-110. PMID: 18031300
A comprehensive review of the state of science regarding cancer stem cells (CSCs), a subset of cells found within tumors and hematological malignancies and theorized to be responsible for starting and maintaining cancer. The authors are from the Institute for Systems Biology, the Seattle Neuroscience Institute, and the Department of Chemical and Biomolecular Engineering & Institute for Genomic Biology at the University of Illinois, Urbana-Champaign.
From the conclusion:
"The identification and prospective isolation of CSCs from leukaemia and a number of solid tumours has spawned a new paradigm in cancer research. From the perspective of systems biology – with the goal of predictive, preventive, personalized, and participatory (P4) medicine – we envision increasingly global assessment of CSCs and their microenvironments (niche) at the level of complete transcriptome, proteome and epigenome, using empowering new high-throughput technologies. The resulting gene expression profile signatures of cancer stem cell would serve as more accurate indicatives for cancer diagnosis and prognosis. Emerging proteomic technologies employing MS and protein chip platforms would allow for identification of better cell-surface markers and their interaction with the resident stem cell niche and potential diagnostic markers from both body fluids and tumour tissues. Incorporating these data into biological networks will provide fundament insights into the biology of CSCs and their abilities for renewal and differentiation. These combined efforts will ultimately lead to new therapeutic strategy specifically targeting CSCs for unprecedented personalized cancer therapy."
OncologyWatch: Posts about free-access articles on aspects of oncology theory, practice and policy (about the blogger). This blog is not a source for medical advice.
Technorati tags:
oncology cancer systems biology
Comments and Links Welcome!
Hi, I really like your thoughts and ideas and wish to exchange ideas.
Please visit my blogs if you have some time:
American Blog
American Classic
American Idols
American Traveler
Planet America
Thank you very much.
Comment by American Traveler — September 1, 2008 @ 10:06 am