oncologywatch

Thor PJ, Krolczyk G, Gil K, et al. Melatonin and serotonin effects on gastrointestinal motility. J Physiol Pharmacol. 2007 Dec;58 Suppl 6:97-103. Review. PMID: 18212403

A fascinating essay/review on the therapeutic potential of these hormones for people at risk for colorectal cancer, ulcerative colitis, gastric ulcers and irritable bowel syndrome.

From the conclusion:

The intelligent modulation of the gastrointestinal motility with melatonin/serotonin on brain-gut axis may be a key point in the treatment of patients resistant to standard therapy functional disorders of GIT. In order to introduce these promising substances into the therapeutic use, basic research for the clear recognition of their interaction and function has to be performed in the nearest future.

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oncology cancer colorectal cancer

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Chelala C, Hahn SA, Whiteman HJ, et al. Pancreatic Expression database: a generic model for the organization, integration and mining of complex cancer datasets. BMC Genomics. 2007 Nov 28;8:439. PMID: 18045474

A brilliant concept, brilliantly executed.

From the abstract:

Pancreatic cancer is the 5th leading cause of cancer death in both males and females. In recent years, a wealth of gene and protein expression studies have been published broadening our understanding of pancreatic cancer biology. Due to the explosive growth in publicly available data from multiple different sources it is becoming increasingly difficult for individual researchers to integrate these into their current research programmes. The Pancreatic Expression database, a generic web-based system, is aiming to close this gap by providing the research community with an open access tool, not only to mine currently available pancreatic cancer data sets but also to include their own data in the database.

The open-source database is available at www.pancreasexpression.org.

Technorati tags:
oncology cancer pancreatic cancer

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